The routine test offered to everyone in the NHS is the combined test. It wasn't refundable if no result unlike the Harmony yet by this point I wasn't considering too much the money. When compared to standard nuchal testing options, the Harmony test is almost 10% more accurate in the diagnosis of Down’s. The harmony test is 99% accurate for gender prediction while an ultrasound is 95% accurate for gender prediction. My doctor told me this would be covered because of my age, but I got a bill for $800. A study published in the Journal of Prenatal Medicine in 2014 documents six cases of false-positive results from Non-Invasive Prenatal Testing (NIPT) – such as the Harmony test – in one Italian testing centre in the space of two months. They are all nipty tests looking at foetal dna in the mothers blood. In had the harmony test and was told it would take 2 weeks. Remember they only look at the trisomies. That being said, I did the free NIPT test and got a positive and then did the Harmony (everything was fine) but it took way longer to come back then they said it would, 2.5 weeks! I felt like my midwife was more comfortable with this test as a result but the decision was 100% mine. My Dr told me about the harmony test. I then had another blood sample drawn (2 tubes). I wasn't expecting that. Personally, from experience unless you’re high risk for any reason I would never do the genetic testing again. The combined test on the NHS would never have given me 1/10000 due to age so we’d have had unnecessary worry, and we were already terrified of miscarriage.The added bonus was the early scan as we knew pregnancy looked viable and dates were accurate. That is computed with your agape, assuming that chance increases with maternal age). Harmony test o safe test salve a tutte le pancine in crisi, vedo che la discussione in merito a questi argomenti è molto dibattuta. Get updates on how your baby develops, your body changes, and what you can expect during each week of your pregnancy by signing up to the Mumsnet Pregnancy Newsletters. I think the accuracy for the main trisomies (Down’s, Edward’s and Patau’s) must be pretty similar across the board. See what Mumsnetters thought of Homepride Slow Cooker Sauces. I had the harmony test about 2 weeks ago. I've just had my 20 week scan and he's very active and everything looks okay but I was told 50% of babies with Downs have normal scans so whilst it's a very good sign it's not a guarantee. One question - how do these tests differ from the ones you get automatically on the NHS? Prenatal cell-free DNA screening. Thank you so much @Nanmumandmidwife! Harmony is done after 10 weeks, there is more data on it as it been around a couple of years longer. NIPT means “ non invasive prenatal test”. Thanks all, that makes sense. Talk widget showing discussions of the day & trending threads, Subscribe to Mumsnet emails direct to your inbox, alexander-house.co.uk/index.php/down-s-syndrome-screening. To ask do you wear your jeans for more than one day? My test came back positive for Trisomy 18 and my doctor advised us to terminate, which we did. They use the same basic science of fetal DNA fragments being founded in maternal blood, but there are several ways of caputuring them.Many people talk about Harmony as though it is the only NIPT, in the same way we might say Hoover to refer to a vacuum cleaner.Harmony have just spent the most on advertising!Many, many other branded tests are available, including SAFE, NIFTY, Panorama etc In principle they all do the same, assessing the chance of fetal trisomy by looking at little bits of fetal DNA in mum’s blood. Yet this didn't put my mind at ease as I know it's not as accurate but I really wanted to avoid an amnio. I was happy with that result. From what I know they are all pretty much the same test under different company names. Whilst working in the NHS I met far too many people who had test x done and were then given a result of concern late on a Friday evening by email with advice to “contact your NHS provider to discuss”. I'm 37 so potentially at a higher risk I guess, but do t want to throw money away unnecessarily.. thank you again. This is page 1 of 1 (This thread has 2 messages.). The basic principle of prenatal testing is to offer an accessible, safe, and accurate test to all pregnant women to identify those with increased chromosomal abnormalities. 5. Who does the test? In my local area they only offer the Harmony test, but I can travel to London if necessary. Author Topic: MOVED: Harmony vs Safe test NIPT Tests (Read 1417 times) This indicates that SAFE is the one to go for, but it seems to be the hardest test to find: alexander-house.co.uk/index.php/down-s-syndrome-screening. Our clinic phones people first though if a high risk result is found.Because we live rurally there was only one clinic within an hour of us so we had no choice of which test to use unless we spent even more money travelling. All the waiting and stress and upset in between test results was painful. : Hi ladies! I can't say that I'm 100% relaxed because of those Harmony tests. I had mine at what I thought was 10+3 but they thought 10+2 based on measurements. Harmony Prenatal Test (NIPT), the proven option for safe, early, accurate prenatal testing In the rapidly evolving world of Non-Invasive Prenatal Testing (NIPT), the Harmony Prenatal Test offered by Dynacare is demonstrating distinct advantages that set it apart from the competition, enabling it to meet the needs of women worldwide. The clinic I went to recommended the SAFE test (which iirc is the NHS's version of the IONA test) over the Harmony test, because it has a much lower redraw rate. Longest 3 weeks ever. Having said this I've friends who got a result first time with Harmony. Thank you. Could someone please explain the difference? Second pregnancy conceived at 39 and 13 week scan found fluid round baby, decided not to have test as would come back high risk, opted for tfmr when second scab with specialist indicated baby would die anyway. During this time I got a low risk result (1 in 6000) from the combined test. Is it worth taking them before the NHS one? Having said this I've friends who got a result first time with Harmony. My last OB suggested me to do NIFTY test around 11 weeks, but new OB's nurse suggested me to do Harmony test instead of NIFTY, also because in their practice they don't do NIFTY any more. Just that really. I paid £300 for this test. That link is really helpful. At 2 weeks and 1 day the dr called the lab and the results were still being processed. Our test is run at a higher speed than NHTSA’s (35 mph vs. 30 mph). Generally the harmony test is more accurate than the current NHS test but it is more accurate for T21 (Down's syndrome) than it is for T13/18 (Edwards and Patau's) and many people don't realise this when they quote the figures Ultimately none of these tests are 100% conclusive I received a refund of my harmony test but what I really wanted was a result. Because of that, it transfers more energy to the car seat and test dummy than the government test does. I have googled, honest, but it's very confusing with different providers pushing different things Thanks all. No-one knows what is ideal for you.These tests will pick up about 70-75% of affected babies. However, in doing this a great many women are worried for no reason.NIPT ignores a averages and looks at fetal DNA. The Harmony Test is the most well-known brand of non-invasive prenatal testing, and works by detecting the baby’s DNA in the mother’s blood from a simple blood test. We chose the harmony simply because that's the company they use at the fmc and we had previously seen the team at Kings and so felt 'safe' with them. The test is able to screen your developing baby for the risk of chromosomal abnormalities. Might be wrong be wrong though! latest stats say 13.8% of mothers with no result go on to have babies with chromosome abnormalities so that's in the back of my mind however the combined test and Iona /Safe test gave a low risk result so I'm trying to focus on that. The Birth Company is now able to offer the Covid-19 (SARS-CoV-2) IgG Antibody blood test, at a cost of £100. The Harmony™ test can also look at the fetal sex and detect abnormal numbers of the sex chromosomes. It may be quite normal for you to have higher or lower hormone levels than average. When you say These tests will pick up about 70-75% of affected babies does that mean that the NHS tests miss 25-30% of babies affected and wrongly classify them as "low risk" - that's quite a worrying statistic.Thanks @Megan2018. This means that a significant number of affected babies are not identified. The Harmony prenatal test was developed to be a more accurate prenatal Down syndrome screening test for women of any age or risk category. The SAFE test is done in an NHS accredited lab (at St George’s) and clinicians have ready access to experts in the case of unusual results. Vi racconto la mia esperienza sperando possa chiarirvi i dubbi. It is a DNA-based blood test that has been extensively tested in both the under 35 and over 35 age groups, studies have included pregnant women aged 18-48 for Down syndrome 1-3 . Good luck! I took I the harmony test at 11 weeks 2 days. Basically there's not enough research available yet so there's little understanding. harmony test, is it worth it? How are results given to you? All the waiting and stress and upset in between test results was painful. If you have a choice of tests, check with your insurance company and see what they will cover. The Harmony Test cannot detect twins or multiples in general; therefore, a regular ultrasound will still need to be carried out to determine whether or … Even if it comes back positive your obstetrician will do further test to make sure 100% before u decide what to do. Test results have come back in high risk category of 1:244. Get updates on how your baby develops, your body changes, and what you can expect during each week of your pregnancy by signing up to the Mumsnet Pregnancy Newsletters. Naturally I was upset, stressed and worried. The Harmony cfDNA test can be performed from 10 weeks of pregnancy, two weeks earlier than the NHS 12-14 week screening. The researchers compared Roche’s Harmony test to standard prenatal screening for Down syndrome - which relies on biomarkers in the blood and a fetal ultrasound - … I ended up getting the results exactly 3 weeks. See what Mumsnetters thought of Homepride Slow Cooker Sauces, Talk widget showing discussions of the day & trending threads, Subscribe to Mumsnet emails direct to your inbox, www.arc-uk.org/tests-explained/non-invasive-prenatal-testing-nipt, www.qmul.ac.uk/wolfson/services/antenatal-screening/screening-tests/combined-test/#performance. I personally had Harmony as that was the nearest to me. It was totally worth the money for us (£399), I conceived at 40, DH was 45 (41 and 46 at birth). It is quite expensive but I'd rather do a non evasive safe test for peace of mind. It had to be when at least 10 weeks to collect enough fetal DNA to test. I think limited choice is sometimes helpful!Our hospital offered NIPT at a cheaper price (£250) but only after 12 week scan (as they don’t include a scan for NIPT, bloods only), which for me was too late as I’d have been nearly 14 weeks rather than 11 when results known, and for bad news that difference mattered. I decided to do the Iona / Safe NIPT as a last attempt. I decided to do the Iona / Safe NIPT as a last attempt. They said that the testing process is different and less DNA fraction. Yet I'm in the unlucky 2% so I'm sure you and others reading this will be fine but from my experience I wish I had never taken the Harmony test and only the Iona as I would of avoided a lot of stress and upset and have no lingering doubt throughout the rest of my pregnancy. To use this feature subscribe to Mumsnet Premium - get first access to new features see fewer ads, and support Mumsnet. The SAFE test has a greater sensitivity, specificity and higher positive predictive value (PPV) than the Nuchal Translucency screening, also known as the Combined Test. Do they have expert knowledge to discuss with you what tests are appropriate in your specific situation ? There are many other genetic chromosomal conditions available. Highly recommend it, it will tell u 99.9% if your child has any of the genetic abnormalities. @FoxtrotSkarloey is right, and there are also lots of other “brands” of NIPT available. It is more reliable for Downs than for Edwards or Pataus.3. Any advice or experiences would be really helpful, thanks in advance. Appointments available at short notice. Testul Prenatal Harmony necesita prelevarea unei probe de sange si poate fi realizat incepand cu a 10-a saptamana de sarcina. Where is the test processed? Internationally NIPT is only considered valid & reliable for tri 21, q18 and 13. Although I am not high risk and we'll under 35 which is when you usually take the test, I'm considering on taking it. The Harmony Prenatal Test is an advanced yet simple screening test to detect for levels of Down Syndrome, Edwards and Patau’s in an unborn baby. The Harmony Prenatal Test promises to help you do that. I told the provider I had 4 inconclusive / no results with the Harmony test. If I was your age I would probably have the nhs test first and then decide based on how low/high risk you are. This is page 1 of 1 (This thread has 15 messages.). Conceived at 40 and will be 41 when give birth I opted for prenatal safe test which comes back really quickly (tested Tues, resukts Fri) , is 99.9 accurate, but only comes back either low risk or high risk--no numbers. My usual advice would be to have the routine first trimester scan & combined test & the discuss with someone who really knows what they are talking about and is keen to understand your thoughts, feelings and priorities. This time around.. Yourgene Health plc is a UK based molecular diagnostics company working in partnership with St George’s University NHS Hospitals Foundation Trust to create a UK Centre of Excellence in bringing the first regulated NIPT test to more pregnant women. I had mine at what I thought was 10+3 but they thought 10+2 based on measurements. The Harmony test can detect approximately 99% of fetuses affected with Down syndrome (Trisomy 21), 98% of fetuses with Trisomy 18, and a large number of pregnancies with Trisomy 13. I was 16 weeks pregnant. I had the harmony test. The Harmony test is a version of NIPT (Harmony is a brand name - another version of the same thing is name Percept). To have initially been mortified but now a bit annoyed by call from school? The SAFE test is a CE-marked in vitro diagnostic test from Yourgene Health plc (The IONA® test). Hi Ladies, I am 10 weeks now, trying to make an appointment for my 12 weeks check-up with my OB. I'm 38 and unexpectantly got pregnant. A lot depends what you might do with the information that such tests provide. We were advised we could have further tests done of either the Harmony Prenatal Test or Amniocentesis. Our results were 1/10000 for everything tested and scans were clear. Has anyone had the Harmony Prenatal Test done? I lived abroad for 10 years and there NIPT is normal for over 35's. The test … This blood test examines fetal DNA in the maternal bloodstream to screen for the increased chance for specific … The Harmony test offers near total accuracy in diagnosing chromosomal conditions such as Down Syndrome. I think some tests don’t offer sex, Harmony does though. We didn’t want to continue the pregnancy if any of the trisomies were found and the risk score from the combined test would definitely have been higher due to the age factor. This test has now become one of the most predictive, accurate and non-invasive tests available to check the chances of your baby having a chromosomal abnormality. I waited 7 working days as they had a problem in the lab (yes how lucky can you be) however they gave me a low risk result ( 1 in 50,000 for all 3) with the first blood sample which was taken just 2 days after the 2nd Harmony test blood draw so wouldn't of been much difference in the DNA levels. I am undecided at the moment. I want to be sure that you understand the pros & cons. Just a little food for thought...Very happy to discuss further if anyone is interested. @CatintheFireplace I didn't have a nipt test my first pregnancy- 38 conceived, 39 gave birth. NHS results came back 1 in 6000 and 1 in 7000 for other trisonomies. I wanted to know early if we needed to terminate.Obviously we still had some concerns at 12 and 20 week scans of other issues being found but we didn’t need to consider amnio or CVS so it was worth it for us. Read the info here www.arc-uk.org/tests-explained/non-invasive-prenatal-testing-niptAs others have said there are various brands of NIPT, they are all quite similar though. You get a pen assessment of chance. The advertising standards authority recently won cases against several providers.2. I thought SAFE and Harmony were 'brand names' for NIPT tests, but they work the same and test the same? I personally had Harmony as that was the nearest to me. Important issues to consider:1.this is always a screening test - it is not a certain diagnosis. The test can also help detect neural tube defects — serious abnormalities of the brain or spinal cord. I know lots of people who have been high risk on NHS and then low risk on nipt. It's quite expensive though so I wanted to know what your reasons were for taking it? I feel it is important to at least in principle have thought a bit about “what if”. While no test is foolproof, Emily’s case is far from isolated. I waited 7 days to be told again not enough DNA. Resulta later found it was t21. Based just on your age, you have around a 1-in-1,400 chance of having a child with Down syndrome. much higher detection rate for Down syndrome than the previous test method The Harmony prenatal test analyses a blood sample from the expectant mother during her pregnancy from week 10. Even the Harmony test result says 2%, though I’m not exactly sure what Harmony is reporting with that number. The prenatal test is offered by Ariosa Diagnostics. They said they'd test the 2nd sample they took and I must wait another 5-7 working days. I had the Harmony test on 7/16 and I'm still waiting for results. They said that the testing process is different and less DNA fraction. Thanks @Nanmumandmidwife, that's really helpful. Needless to say, I am a nervous wreck right now! Some test labs will take samples from anyone with no quality control, or assessment of the ability to give appropriate information/counselling/ support to clients in the case of a concerning result 7. I wish I had opted for the Materniti21 test, which I did in March. Some test for additional syndromes, but I understand that these results aren’t as accurate as for the main trisomies. Claritate in timp util. To ask do you wear your jeans for more than one day? That is a statistical assessment of chance, looking at how “average” your results are for the nuchal translucency measurement (back of baby’s neck) and two hormones in your blood. The only number that tells you your probability for having a child with Down syndrome is the positive predictive value . To use this feature subscribe to Mumsnet Premium - get first access to new features see fewer ads, and support Mumsnet. 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